ABSTRACT
O insulinoma é um tumor das células ß do pâncreas, que têm a função de produzir e secretar insulina e, geralmente são malignos em cães. O presente trabalho descreve o diagnóstico e o manejo terapêutico de três casos de insulinoma. Os sinais clínicos dos animais relatados variaram de acordo com a severidade e a duração da hipoglicemia. O diagnóstico presuntivo se deu através dos sinais clínicos e da dosagem de insulina sérica no momento de mais intensa hipoglicemia e, o diagnóstico definitivo foi obtido por meio de exame histopatológico nos três casos relatados. O tratamento realizado variou de acordo com a intensidade dos sinais clínicos.(AU)
Insulinoma is a tumor of the ß cells of the pancreas, which have the function to produce and secrete insulin and are usually malignant in dogs. This paper describes the diagnosis and therapeutic management of three cases of insulinoma. The clinical signs reported animals varied according to the severity and duration of hypoglycemia. The presumptive diagnosis was based on clinical signs and serum insulin dosage at the time of hypoglycemia and more intense, the definitive diagnosis was made by histopathological examination in three of the reported cases. The treatment was varied according to the severity of clinical signs.(AU)
Subject(s)
Animals , Female , Dogs , Hypoglycemia/veterinary , Insulinoma/diagnosis , Insulinoma/therapy , Insulinoma/veterinary , Pancreatic Neoplasms/veterinaryABSTRACT
Undifferentiated carcinoma of the pancreas is a malignant neoplasm that is uncommon among domestic species, especially cockatiels (Nymphicus hollandicus), one of the most popular birds kept as a pet throughout the world. The aim of this study was to describe the occurrence of an undifferentiated carcinoma in the pancreas of a cockatiel. A bird, an adult male that died naturally with swelling in the abdominal region, was referred to necropsy. Macroscopic examination showed poor body condition, the coelomic cavity filled with liquid and a white mass attached to the pancreas and other smaller masses attached to the duodenum. Tissue samples and organs were harvested and fixed in 10% buffered formalin, then routinely processed for histopathology and stained with hematoxylin and eosin. Microscopic analysis demonstrated an epithelial neoplasia with a predominantly solid pattern, lymphatic invasion and involvement of the intestinal serous membrane. These findings indicate the occurrence of an undifferentiated pancreatic carcinoma in a cockatiel that was diagnosed by histopathology.(AU)
O carcinoma indiferenciado de pâncreas é uma neoplasia maligna, incomum entre as espécies domésticas, especialmente em calopsitas (Nymphicus hollandicus), uma das aves mais populares como animal de companhia no mundo. O objetivo deste trabalho foi descrever a ocorrência de carcinoma indiferenciado de pâncreas em Nymphicus hollandicus. Uma ave, macho adulto, com morte natural e com aumento de volume em região abdominal, foi encaminhada para necropsia. Ao exame macroscópico foram observados mau estado corporal, cavidade celômica repleta de líquido e massa esbranquiçada aderida ao pâncreas e outra menor aderida ao duodeno. Amostras de tecidos e órgãos foram colhidas em formol 10% tamponado, processadas rotineiramente para histopatologia e coradas por hematoxilina e eosina. Na microscopia foi observada neoplasia epitelial com padrão predominantemente sólido, com invasão linfática e implantação na serosa intestinal. Com esses achados, comprovou-se a ocorrência de carcinoma indiferenciado de pâncreas em Nymphicus hollandicus, o qual pode ser diagnosticado por meio de histopatologia.(AU)
Subject(s)
Animals , Carcinoma/veterinary , Cockatoos , Pancreatic Neoplasms/veterinary , Pancreas/pathologyABSTRACT
A 7-year-old castrated male German shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. Laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. Provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. In exploratory laparotomy a small nodular mass was detected on the pancreas. Other abdominal organs were normal in gross inspection. The mass was removed surgically. Histopathology of the excised pancreatic nodule confirmed the diagnosis of insulinoma. The dog became seizure free following the surgical operation
Subject(s)
Male , Animals , Hypoglycemia/diagnosis , Hypoglycemia/therapy , Disease Management , Insulinoma/veterinary , Pancreatic Neoplasms/veterinary , Dogs , Lethargy/veterinary , Seizures/veterinary , Hyperinsulinism/veterinaryABSTRACT
Luego de efectuar una síntesis sobre la aplicación de la oclusión ductal en el trasplante del páncreas a fin de evitar las complicaciones postoperatorias, los autores presentan 68 estudios histopatológicos de páncreas de perros cuyo sistema canalicular fue bloqueado con distintas sustancias. Se analizan los diferentes hallazgos, donde se demuestra comparativamente la temprana fibrosis provocada con thibloc y silicona, mientras que al emplear Tissucol no se observaron secuelas fibróticas. La fibrosis puede ser la responsable de las fallas alejadas del injerto, debido a los trastornos que provoca en la microcirculación del islote y a la posible ausencia de fenómenos regenerativos originados en la destrucción del epitelio ductal; sugieren al Tissucol como agente bloqueante del injerto previo a su trasplante.